参松养心胶囊联合小剂量倍他乐克治疗频发室性早搏临床研究

目的:评价参松养心胶囊联合小剂量倍他乐克治疗频发室性早搏的临床有效性及安全性。方法:收集2011年1月—2011年12月在我院门诊和住院诊断为频发室性早搏(频率≥30次/h)的患者,按就诊顺序将合格受试者分为对照组和治疗组。对照组:常规口服美托洛尔缓释片(23.75mg/d);治疗组33例,在常规口服美托洛尔缓释片基础上加服参松养心胶囊(每次4粒,每日3次)。门诊随访1次/周,疗程为2周,结束后比较两组患者临床症状、24h动态心电图变化之间的差异。结果:共纳入受试者65例,对照组32例,治疗组33例。治疗前两组受试者的年龄、性别、房颤发作频率等比较差异无统计学意义。经2周治疗后,治疗组室性早搏发作次数明显减少,总有效率(90.9%)明显高于对照组(78.1%),差异有统计学意义(P

Clinical Study of Frequent Premature Ventricular Contractions Treated by Shenysong Yangxin Capsule Combined with Low Dose of Metoprolol

Objective:To evaluate the clinical effectiveness and security of frequent premature ventricular contractions(FPVC)treated by Shenysong Yangxin capsule combined with low dose of metoprolol.Methods:Gather patients with FPVC(frequency ≥ 30 times / h)diagnosed in our clinic and hospital from January 2011 to December 2011 were selected.Qualified subjects were divided into control group and treatment group according to the treatment order.Control group was administrated metoprolol tablets(23.75mg/d)conventionally by oral;treatment group was administrated metoprolol tablets conventionally by oral combined with Shenysong Yangxin capsule(four capsules each time and 3 times a day).Patients were followed up once a week,and the period of treatment was 2 weeks.Then,the differences of their clinical symptoms and the 24h ambulatory ECG changes separately between the two groups were compared and explored.Conclusion:A total of 65 cases of the subjects was gathered with 32 cases in the control group and 33 cases in the treatment group.There was no significant difference between the two groups of subjects’ age,gender and atrial fibrillation frequency before treatment.But the number of attacks of FPVC in the treatment group decreased significantly and the total efficiency(90.9%)was significantly higherthan that(78.1%)of the control group(P<0.05).And the degree of improvement of main symptoms in the treatment group was significantly higher than that of the control group(P<0.05).Besides,no serious adverse reaction was found in the two groups.Conclusion:The treatment of FPVC by Shenysong Yangxin capsule combined with low dose of metoprolol is safe,effective and earned clinical value.