Ras基因和c-myc基因在结节性甲状腺肿合并甲状腺癌中的表达

目的:探讨正常甲状腺组织和结节性甲状腺肿合并甲状腺癌中Ras基因和c-myc基因的表达。方法:采用LSAB法作免疫组化染色检测了20例结节性甲状腺肿旁正常甲状腺组织和40例结节性甲状腺肿、40例结节性甲状腺肿合并甲状腺癌中Ras和c-myc基因的表达。结果:Ras和c-myc基因在甲状腺正常组织中均呈阴性。在40例结节性甲状腺肿合并甲状腺癌中Ras和c-myc基因的阳性表达率分别为52.5%和77.5%。结节性甲状腺肿合并甲状腺癌中Ras和c-myc基因的表达呈明显正相关(P<0.05)。结论:Ras和c-myc基因在结节性甲状腺肿合并甲状腺癌的发生、发展中起到重要作用。

Expressions of Ras gene and C-myc gene in Thyroid of Nodular Goiter complicated with Thyroid Cancer

Objective: To explore expressions of Ras gene and C-myc gene in nodular goiter complicated with thyroid cancer and normal thyroid tissues.Methods: Immunohistochemistry method-LSAB was used to detect expressions of Ras gene and C-myc gene in nodular goiter complicated with thyroid cancer(40 cases),normal thyroid tissues(20 cases) and thyroid cancer(40 cases).Results:The negative expression of Ras gene and C-myc gene in normal thyroid tissues;The positive expression rates of Ras gene and C-myc gene were 52.5% and 77.5% in nodular goiter complicated with thyroid cancer;There's positive correlation of expressions of Ras gene and C-myc gene in nodular goiter complicated with thyroid cancer(P<0.05).Conclusion: It play an important role of expressions of Ras gene and C-myc gene in nodular goiter complicated with thyroid cancer during the development.