血管内皮生长因子与微血管密度在良性前列腺增生中的表达

目的：探讨血管内皮生长因子（vascular endothelial growth factor,VEGF）与微血管密度（microvascular density，MVD）在良性前列腺增生（benign prostatic hyperplasia，BPH）中的表达情况及其在BPH血管生成中的作用。方法：应用VEGF、MVD的免疫组化S—P染色法分析23例BPH中VEGF及MVD的表达情况。结果：中央区VEGF表达阳性率为54．35％，周边区VEGF表达阳性率为13．48％，二者差别有高度统计学意义（P〈0．01）；BPH中央区平均MVD值为（20．39±6．45），周边区平均MVD值为（7．45±4.34），二者差别有高度统计学意义（P〈0．01）；BPH中VEGF表达强度与MVD值之间呈正相关（r=0．8634，P〈0．05）。结论：VEGF是促进BPH内血管生成的重要因素。

The expressions of vascular endothelial growth factor and microvascular den-sity in benign prostatic hyperplasia

Objective：To investigate the expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia, as well as the effects on the angiogenesis of BPH. Metheds：Immunohistochemical S-P assay was used to investigate the expressions of vascular endothelial growth factor and microvascular density in twenty-three cases of BPH. Results：The positive rates of VEGF in the center part and circumjacent part of BPH were 54.35% and 13.48% respectively, and it showed a significant difference（P〈0.01）. The average MVD values in the center part and circumjacent part of BPH were（20.39±6.45）and（7.45±4.34）respectively, and it also showed a significant difference（P〈0.01）. There was a correlation between VEGF expression and MVD value（r=0.863 4, P〈0.05）o Conclusion ：VEGF is a key factor in promoting the BPH angiogenesis.