HLA-A2 reactive antibodies in a patient who types as HLA-A2: The importance of high resolution typing and epitope-based antibody analysis |
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| Affiliation: | 1. Transplantation Immunology Laboratory, Department of Surgery, Albany Medical College, Albany, NY, United States;2. Section of Transplantation, Department of Surgery, Albany Medical Center, Albany, NY, United States;3. Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States;1. INSERM U1151, Paris, France;2. Université Paris Descartes, Sorbonne Paris Cité, Paris, France;3. Service de Néphrologie et Transplantation Adulte, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France;4. Laboratoire d’anatomie pathologique, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France;5. RTRS Centaure, LabEx Transplantex |
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| Abstract: | This report describes a case of a highly sensitized patient who had serum antibodies reacting with HLA-A2 but whose phenotype included HLA-A2. The determination of HLA mismatch acceptability at the antigen level was problematic, but high-resolution HLA typing information and epitope-based antibody specificity analysis based on the nonself-self paradigm of HLA epitope immunogenicity have provided a solution. This case supports the concept that HLA typing at the allele level offers a better approach to identifying suitable donors for sensitized patients. |
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