IgA1 protease production by bacteria colonizing the upper respiratory tract |
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Authors: | J Zakrzewski cand med T Bechert Prof Dr med J -P Guggenbichler |
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Institution: | 1. Universit?tsklinik für Kinder und Jugendliche, Loschgestr. 15, D-91054, Erlangen, Germany
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Abstract: | Summary Thirty-eight clinical isolates ofHaemophilus influenzae and ten clinical isolates ofStreptococcus pneumoniae were examined for IgA1 protease production. A suspension of surface material of each individual strain was incubated with
human secretory IgA; IgA1 cleavage products were detected by SDS-PAGE and immunoblotting. The high incidence of IgA1 protease-positive
strains (68.4% of the examinedH. influenzae and 100% of the examinedS. pneumoniae strains) confirms that IgA1 protease activity is a frequent characteristic of these two species. Yet the presence of this
enzyme is, if at all, only a minor decisive factor for the induction of symptomatic infections of the upper respiratory tract
by IgA1 protease-positive bacteria. |
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