多奈哌齐治疗阿尔茨海默病的临床观察

目的探讨多奈哌齐对阿尔茨海默病患者认知功能和日常生活能力的治疗作用。方法收集阿尔茨海默病患者140例,随机分为治疗组70例与对照组70例,治疗组采用多奈哌齐,对照组不使用多奈哌齐治疗。两组患者分别在治疗前、治疗后1个月、3个月、6个月进行MMSE和ADL评分。结果治疗组经多奈哌齐治疗后MMSE和ADL评分较对照组有明显改善,随治疗时间延长两组间差异增大即治疗作用增强,且均具有统计学差异（P〈0.05）。治疗1个月、3个月和6个月后,多奈哌齐对AD患者认知功能改善的总体有效率分别高出对照组13%、32%、43%,对日常生活能力改善的总体有效率分别分别高出对照组8%、13%、23%,与对照组相比多奈哌齐疗效显著（P〈0.05）。结论多奈哌齐对阿尔茨海默病患者认知和日常生活能力有显著改善作用。

Clinical observation of effect of donepezil in treating Alzhemer's disease

Objective To investigate the effect of donepezil in treating patients with Alzheimer＇s disease on cognitive disfunction and lacking of capablity of daily living.Methods140 patient＇s with Alzheimer＇s disease were randomly divided into treatment group（treated with donepezil）and control group（treated without donepezil）.MMSE Scale and ADL Scale of the two groups were assessed before treatment and 1 months、3 months and 6 months af ter treatment.ResultsThe MMSE Scale and ADL Scale of the treatment group were improved more greatly than the control group（P0.05）,and the therapeutical effect enhanced as the time of therapy expanded.After treated with donepezil for 1 month、2 months、6 months,the effective percentage of donepezil in treating AD patients with congnitive disfunction are respectively13%、32%、43%hgher than without donepezil,and in treating AD patients lacking of capablity of daily living are respectively 8%、13%、23%hgher than without donepezil.ConclusionDonepezil effectively improves cognition and preserves function in individuals with Alzheimer＇s disease.