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| Effects of tanshinone on neuropathological changes induced by amyloid β-peptide(1-40)injection in rat hippocampus | |
| 作者姓名： | Long-xuan LI2 Jia-pei DAI3 Li-qiang RU4 Guang-fu YIN4 Bin ZHAO Department of Neurology Affiliated Hospital Guangdong Medical College Zhanjiang 524001 China 3The Netherlands Institute for Brain Research Amsterdam 1105AZ the Netherlands 4Department of Neurobiology TongjiMedical College of Huazhong Universityof Science and Technology Wuhan 430030 China |
| 作者单位： | Long-xuan LI2，Jia-pei DAI3，Li-qiang RU4，Guang-fu YIN4，Bin ZHAO Department of Neurology，Affiliated Hospital，Guangdong Medical College，Zhanjiang 524001，China; 3The Netherlands Institute for Brain Research，Amsterdam 1105AZ，the Netherlands; 4Department of Neurobiology，TongjiMedical College of Huazhong Universityof Science and Technology，Wuhan 430030，China |
| 基金项目： | Project supported by the National Natural Science Foundation of China, No 30171082. |
| 摘 要： | INTRODUCTION Alzheimer’s disease (AD) is characterized by neu-ronal loss and extracellular senile plaque, whose majorconstituentis amyloid β-peptide(Aβ), a 39-43 amino acidspeptide derived from amyloid precursor protein (APP).It is widely believed that the cellular actions of Aβ areresponsible for the neuronal cell loss observed in ADand play a causal role in the pathogenesis of AD[1,2].Aggregated Aβ and its activefragmentshave beenshownto have clear neurotoxic effect[3]. … |
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