Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity |
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Authors: | WMS TSUI AKT YUEN KF MA CCH TSE |
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Institution: | Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong. |
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Abstract: | We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means. |
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Keywords: | Keywords liver angiomyolipoma angiomyelolipoma HMB-45 |
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