INFLUENCE OF SUXAMETHONIUM ON THE POTENCY OF ORG NC 45 IN ANAESTHETIZED PATIENTS

The non-depolarizing neuromuscular block produced by Org NC45was potentiated by the previous administration of suxamethonium1 mg kg^–1, shown by twitch depression of 91.3±2.4%when the same dose of Org NC 45 was administered after recoveryfrom suxamethonium compared with the control value of 71.9±6.5%.The recovery index was also prolonged from 8.1±0.3 to10.4±1.0min after suxamethonium. The dose-response curvesfor Org NC 45 showed a 1.66 potentiation factor for ED₅₀ and1.73 for ED_9.5, caused by the previous administration of suxamethonium.This interaction is likely to occur in the plasma.