抑肽酶对心脏手术血液保护量效关系的研究

目的 对抑肽酶的不同使用剂量和止血效果进行比较分析，探讨最佳应用方案。方法 ８２例心脏手术病人分为大剂量、半量和小剂量抑肽酶组，以不同的给药方案进行引流量、血制品用量、血红蛋白丢失量和血液抑肽酶浓度检测。结果 大剂量抑肽酶组与对照组相比，术后１２、２４ｈ引流量减少５４％、５５％，总红蛋白丢失量减少５６％。总血制品用量减少６５％。半量抑肽酶组可使术后１２、２４ｈ引流量减少４９％和５５％，与大剂量抑肽

The Blood Conservation Research on Aprotinin Dosages and Effects in Cardiac Surgery

Objective Different aprotinin regimens and their hemostatic effects were comparatively analysed and the more appropriate aprotinin regimen was evaluated and discussed here. Methods Eighty two open heart patients were divided into three groups.There were high dose half dose and low dose aprotinin groups.Results It was shown that the high dose aprotinin regimen could reduce postoperative drainage by 54%and 55%during the first 12 and 24 hours,meanwhile the hemoglobin loss and blood transfusion requirement were reduced by 56%and 65% respectively compared to the control group. The half dose aprotinin regimen could reduce postoperative drainage by 49% and 55% in the first 12 and 24 hours ,which was not significantly different as compared with high dose aprotinin group.The low dose aprotinin regimen could reduce tube drainage and blood transfusion requirement by 30% and 26% ,which had significant difference as compared to half dose aprotinin group. Conclusion The use of aprotinin could significantly reduce postoperative drainage and blood transfusion requirement,the hemostatic effect was related to aprotinin dose.The half dose and low dose aprotinin regimen are recommended.