Influence of general anesthesia on acute experimental poisoning of cats with the organophosphorus pesticide Anthio |
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Authors: | I A Tarakanov Ya K Kurambaev V A Safonov |
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Institution: | (1) Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | It is shown that general anesthesia strongly influences the resistance of animals to poisoning with organophosphorus compounds
(OPC) such as Anthio, weakens compensatory/adaptive responses, and possibly acts synergistically with OPC in impairing tissue
respiration. One to three days after peroral administration of Anthio, reduced oxygen tension in arterial blood and increased
heart and respiratory rates were recorded in cats, although the arterial blood pressure tended to drop markedly. Anthio poisoning
led to profound changes in the autonomic regulation of functions, which was manifested in sharply decreased parasympathetic
influences. The function of the brain's GABA-ergic system did not change appreciably.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
6, pp. 587–590, June 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences |
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Keywords: | cats anesthesia organophosphorus compounds acute poisoning Anthio pesticide |
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