The calcium channel antagonist diltiazem effectively blocks two types of potassium channels in the neuronal membranes |
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| Authors: | Yu V Bukanova E I Solntseva |
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| Institution: | (1) Laboratory of Functional Synaptology, Institute of the Brain, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Effect of the Ca2+-channel antagonist diltiazem on potential-operated Ca2+ and K+ currents was studied on isolated edible snail neurons by a two-microelectrode patch-clamp technique. Diltiazem in a concentration
of 0.1 mM inhibits Ca2+ current, high-threshold Ca2+-dependent K+ current, and Ca2+-independent K+ current and has no effect on low-threshold K+ current and leakage current. It is suggested that therapeutic effect of diltiazem is mediated through blockade of Ca2+ and K+ channels.
Tranlated fromByulleten' Eksperimental'noi biologii i Meditsiny, Vol. 124, No. 9, pp. 271–274. September, 1997 |
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| Keywords: | K + channels Ca 2+ channels Ca 2+ antagonists diltiazem snail neurons |
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