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Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis |
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| Authors: | Angela Pyle David J. Burn Charlotte Gordon Catherine Swan Patrick F. Chinnery Simon V. Baudouin |
| Affiliation: | (1) Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Framlington Place, Newcastle, NE2 4HH, UK;(2) Clinical Ageing Research Unit, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle, NE4 5PL, UK;(3) Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK;(4) Critical Care Unit, Royal Victoria Infirmary, Newcastle, NE1 4LP, UK; |
| Abstract: | PurposeLoss of mitochondrial DNA (mtDNA) has been described in whole blood samples from a small number of patients with sepsis, but the underlying mechanism and clinical implications of this observation are not clear. We have investigated the cellular basis of the mtDNA depletion in sepsis, and determined clinical correlates with mtDNA depletion. |
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