Meropenem Alone and in Combination with Vancomycin in Experimental Meningitis Caused by a Penicillin-Resistant Pneumococcal Strain期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Meropenem Alone and in Combination with Vancomycin in Experimental Meningitis Caused by a Penicillin-Resistant Pneumococcal Strain

Authors:	C M Gerber M Cottagnoud K A Neftel M G Täuber P Cottagnoud

Institution:	(1) Department of Internal Medicine, Inselspital, 3010 Berne, Switzerland e-mail: pcottagn@insel.ch, CH;(2) Department of Internal Medicine, Zieglerspital, 3007 Berne, Switzerland, CH;(3) Institute for Medical Microbiology, University of Berne, 3010 Berne, Switzerland, CH

Abstract:	In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 μg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (–0.48±0.14 Δlog₁₀ cfu/ml·h) and slightly superior to ceftriaxone (–0.34±0.23 Δlog₁₀ cfu/ml·h) and vancomycin (–0.39±0.19 Δlog₁₀ cfu/ml·h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (–0.55±0.19 Δlog₁₀ cfu/ml·h), only an insignificant gain was observed by the addition of vancomycin to meropenem (–0.55±0.28 Δlog₁₀ cfu/ml·h).

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