硫酸依替米星治疗75例急性细菌性感染

目的:评价硫酸依替米星注射液治疗急性细菌性感染的临床疗效与安全性。方法:以进口硫酸奈替米星注射液为对照药进行随机对照临床试验,共治疗住院患者95例,其中随机对照组42例(试验组22例、对照组20例)、开放组53例。硫酸依替米星与奈替米星均为每次 100 mg,q12h静脉滴注,疗程 7~10 d。结果:试验组、对照组和开放组的痊愈率与有效率分别为68.8%与90.91%、65.00%与90.00%和66.04%与084.91%。细菌清除率试验组为95.45%、对照组为100.00%、开放组为92.59%。不良反应发生率3组分别为 9.10%、5.0%和 7.55%。试验组和对照组以上各项指标比较差异均无显著性(P＞0.05)。结论:国产硫酸依替米星注射液治疗急性细菌性感染疗效确切、使用安全。

Etimicin sulfate in the treatment of 75 cases with acute bacterial infections

To evaluate the efficacy and safety of etimicin in the treatment of acute bacterial infections.A ran-domized controlled clinical tria1 was conducted and netilmicin was chosen as control. Ninty-five hospitalized patients were enrolled.There were 22, 20 and 53 patients in test, control and open group respectively. The dosage both drugs was 100 mg every 12 hoursby intravenous infusion. The duration of treatment was 7-10 days. The cure rates and the overall effective rates were 68.18%, 90.91% for test group, 65.00 %, 90.00 % for control group and 66.04 %, 84.91 % for open group.The bacterial eradicationrates were 95.45 %, 100.00 % and 92.59 % respectively. The incidence of adverse drug reactions were 9.10 %, 5.0 % and 7.55% respectively. There was no significant differences between the test and control groups (P>0.05).Etimicin is effec-tive and safe in the treatment of acute bacterial infections.