| 西多福韦的合成 |
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| 引用本文： | 卢宁,彭英丹,傅磊,张健存.西多福韦的合成[J].中国新药杂志,2007,16(16):1272-1274. |
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| 作者姓名： | 卢宁 彭英丹 傅磊 张健存 |
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| 作者单位： | 上海交通大学药学院,上海,200240 |
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| 摘 要： | 目的:合成西多福韦。方法:以(R)-缩水甘油为原料,经保护羟基、与碱基缩合,保护氨基,与侧链缩合和脱保护等反应合成西多福韦。结果:目标化合物经核磁共振氢谱、红外、熔点等确证其化学结构,总收率达22%。结论:该路线反应条件温和,步骤较短,适合工业化生产。
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| 关 键 词： | 西多福韦 无环核苷 抗病毒药 |
| 文章编号： | 1003-3734（2007）16-1272-03 |
| 收稿时间： | 2007-05-09 |
| 修稿时间： | 2007年5月9日 |
Synthesis of cidofovir |
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| LU Ning,PENG Ying-dan,FU Lei,ZHANG Jiancun.Synthesis of cidofovir[J].Chinese Journal of New Drugs,2007,16(16):1272-1274. |
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| Authors: | LU Ning PENG Ying-dan FU Lei ZHANG Jiancun |
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| Institution: | School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | Objective:To synthesize cidofovir.Methods:(R)-glycidol was used as starting material to obtain cidofovir via protection of hydroxyl group,condensation with cytosine,protection of amino group,condensation with side chain and deprotections.Results:The structure of target compound was confirmed by 1H-NMR,IR and melting point.A total yield was 22%.Conclusion:The synthetic process with mild reactive conditions and simplified method is applicable to pilot manufacture. |
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| Keywords: | cidofovir acyclic nucleotide antiviral drug |
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