Polymorphonuclear leukocyte function in psoriasis vulgaris |
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| Authors: | C.T. PEASE M. FENNELL R.C.D. STAUGHTON D.A. BREWERTON |
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| Affiliation: | Department of Rheumatology, Westminster Hospital, London, U.K. |
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| Abstract: | Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age- and sex-matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic substances F-Met-Leu-Phe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis. |
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