18F‐fluorodeoxyglucose and 11C‐acetate positron emission tomography are useful modalities for diagnosing the histologic type of thymoma |
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| Authors: | Hidekatsu Shibata MD Hiroaki Nomori MD PhD Kimiichi Uno MD PhD Kazuya Sakaguchi PhD Rumi Nakashima MD PhD Kenichi Iyama MD PhD Katsumi Tomiyoshi MD PhD Masahiro Kaji MD PhD Tomoyuki Goya MD PhD Takashi Suzuki MD PhD Hirotoshi Horio MD PhD |
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| Affiliation: | 1. Department of Thoracic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;2. Kyorin University Hospital, Tokyo, Japan;3. Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Keio University, Tokyo, Japan;4. Fax: (011) 81‐96‐373‐5532;5. Nishidai Clinic, Tokyo, Japan;6. Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan;7. Department of Pathology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;8. Department of Radiological Science, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;9. Saiseikai Central Hospital, Tokyo, Japan;10. Showa University Fujigaoka Hospital, Kangawa, Japan;11. Tokyo Metropolitan Komagome Hospital, Tokyo, Japan |
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| Abstract: | BACKGROUND: The objective of this study was to clarify the usefulness of positron emission tomography (PET) using18F‐fluorodeoxyglucose (FDG) and carbon 11‐labeled acetate (AC) for predicting the histologic types and tumor invasiveness of thymoma in a multicenter study. METHODS: Forty thymomas were examined using both FDG‐PET and AC‐PET before surgery. The histologic types were type A in 1 thymoma, type AB in 12 thymomas, type B1 in 11 thymomas, type B2 in 7 thymomas, type B3 in 6 thymomas, and type C in 3 thymomas. Tumor invasiveness was assessed by pathologic tumor stage and was identified as stage I in 17 tumors, stage II in 17 tumors, stage III in 4 tumors, and stage IV in 2 tumors. FDG and AC uptake was measured as the maximum standard uptake value (SUV). RESULTS: The FDG‐SUV in type C thymomas was significantly higher than that in the other types (A‐B3; P = .001 – P = .048). The AC‐SUV in type A/AB thymomas was significantly higher than that in the other tumor types (B1‐C; P < .001 – P = .002). All 3 type C tumors had an FDG‐SUV ≥6.3, and all 13 type A/AB tumors had an FDG‐SUV <6.3 and an AC‐SUV ≥5.7. All 17 thymomas that had an FDG‐SUV <6.3 and an AC‐SUV <5.7 were type B1, B2, or B3. Neither the FDG‐SUV nor the AC‐SUV differed significantly between the stages I/II tumors and stage III/IV tumors. CONCLUSIONS: Although neither the FDG‐SUV nor the AC‐SUV can predict the invasiveness of thymomas assessed by tumor stage, they are useful for predicting histologic types of thymoma. Thymomas with an FDG‐SUV <6.3 and an AC‐SUV ≥5.7 almost certainly are types A/AB, which is of considerable prognostic and management significance. Cancer 2009. © 2009 American Cancer Society. |
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| Keywords: | thymoma histologic type positron emission tomography acetate fluorodeoxyglucose |
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