IL‐17‐producing γδ T cells |
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| Authors: | Rebecca L O'Brien Christina L Roark Willi K Born |
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| Institution: | Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO, USA |
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| Abstract: | IL‐17 is produced not only by CD4+ αβ T cells, but also CD8+ αβ T cells, NKT cells, and γδ T cells, plus some non‐T cells, including macrophages and neutrophils. The ability of IL‐17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, γδ T cells are responsible for much of the IL‐17 produced in several disease models, particularly early on. |
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| Keywords: | γ δ T cells Atopy Autoimmunity IL‐17 Immunodeficiency Infection Inflammation |
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