胆红素水平与冠状动脉病变关系的临床研究

目的探讨胆红素水平与冠状动脉病变之间的关系。方法对196患者进行冠状动脉造影。根据冠状动脉病变情况分为4组;冠状动脉正常组(n=30)、轻度狭窄组(n=36)、中度狭窄组(n=52)和重度狭窄组(n=78)。检测各组患者总胆红素、直接胆红素、间接胆红素、总胆固醇(TC)、三酰甘油(TG)、高密度酯蛋白胆固醇(HDL-C)、低密度酯蛋白胆固醇(LDL-C)水平,并进行各组间比较。结果冠状动脉正常组和轻度狭窄组,血浆总胆红素、直接胆红素、间接胆红素均正常,而中度狭窄组和重度狭窄组均明显降低,与正常组和轻度狭窄组比较差异均有统计学意义(P<0.01)。中度狭窄组、重度狭窄组血TC、LDL-C均升高,HDL-C均降低与正常组和轻度狭窄组比较差异有统计学意义(P<0.05)。结论血中胆红素水平与冠状动脉病变呈负相关。

The relationship between total bilirubin levels and severity of coronary artery lesions

Objective To investigate the relationship between plasma total bilirubin levels and severity of coronary artery lesions.Methods 196 patients who underwent coronary angiography were enrolled in the study.The patients were divided into four groups according to the pathological state of coronary artery:normal group(n=30),mild stenosis group(n=36),medium stenosis group(n=52)and severe stenosis group(n=78).The plasma total bilirubin,total cholesterol(TC),triglycerides(TG),lower density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)were determined in all patients.The coronary artery lesions were observed by angiographic imaging manipulation system.The severity of coronary artery disease was detected according to a modified Gensini score.Results The total bilirubin,indirect bilirubin and direct bilirubin were obviously lower in medium stenosis group and severe stenosis group than those in coronary artery mild stenosis group and normal group(P<0.01).The levels of TC,LDL-C were obviously increased in medium stenosis group and severe stenosis group while HDL-C significantly decreased,there was a significant difference between normal group,mild stenosis group and medium group,severe stenosis group(P<0.05).Conclusion The plsma bilirubin levels are negatively correlated with the severity of coronary artery lesions.