琥珀酰胆碱与埃曲可林相互作用的实验及临床研究

为研讨两类肌松药的相互作用,本文研究了琥珀酰胆碱与埃曲可林使用时的药物作用反应。动物实验结果表明:使用琥珀酰胆碱后埃曲可林的作用时间延长,呈现增强作用,而在峰作用时间内,作用强度减弱,呈现拮抗作用。临床作用结果主要为作用增强,表现为埃曲可林起效时间缩短,呼吸抑制及完全恢复时间延长。

Animal experiment and clinical research on interaction of succinylcholine and atracuronium

The interaction of succinycholine and atracuronium was studied both in animal experiment and clinical practiec. The result of the animal experiment showed that when atracuronium was combind with S. C. C, there was no change in onset and maximum depressipn time, but recovery time and duration were signicantlly prolonged (P<0.01), along with the degree of blockade and peak effective time declined (5-10). Clinically, hall intubation paralyzing dose of atracuronium(0.15mg/kg booy weight ED50) and S. C. C (0.5mg/kg ED95) were observed in six patients with checking respiratory parameters. Compaired with atracuronium alone, the onset time was shortened and the time of respiratory depression and recovery were prolonged when atracuronium was used together with S. C. C.