雷公藤的药性文献回顾及其作用机制研究进展

以“雷公藤”为主题词,“药性”、“药性研究”、“机制研究”、“实验研究”等为自由词,在中文数据库如中国期刊全文数据库、维普数据库中检索,以“Tripterygium”,“Tripterygium wilfordii”,"thunder god vine",“Leigongteng”为主题词,“traditional Chinese medicine's property”,“property”,“mechanism shudy”,“experimental study”等为自由词在外文数据库如Medline,EMbase中检索,并跟踪检索相关文献的参考文献,同时参考相关书籍.除去一些重复性研究文献,收集符合相关文献38篇.根据这些文献及相关书籍,首先回顾有关雷公藤药性方面的文献,在此基础上,总结其功效和临床应用,然后对其作用机制的研究进展进行分析.虽然雷公藤及其相关制剂已广泛地应用于治疗各种疾病,但其药性存在争议,作用机制不甚明确,临床应用有欠合理,应该在中药药性理论的指导下,对其作用机制展开研究,以使雷公藤更有效、更合理地应用于临床.

Literature Review of Medicinal Properties and Mechanism Research Process Analysis about Tripterygium wilfordii

To review and analysis the literature of Tripterygium’s property,efficacy,application and mechanism research.Use ’Tripterygium wilfordii’ as the theme word,’medicinal properties’,’medicinal study’,’mechanistic investigation’,’experimental research’ as free words search in Chinese database,such as Chinese periodical full-text database,VIP database retrieval.Use’Tripterygium’,’T.wilfordii’,’thunder god vine’,’Leigongteng’ as the theme word,’traditional Chinese medicine’s property’,’property’,’mechanism shudy’,’experimental study’ as free words search in the foreign language databases such as Medline,EMbase search,besides,tracking their references,and reference some books.Except some repetitive research literature,we collect 38 literature relevant to our purpose.On the basis of these literature and related books,this paper first reviews the related literature of T.wilfordii’s property,than summarizes its efficacy and clinical application,analyses its mechanism research at last.Although T.wilfordii has been widely used in the treatment of various diseases,its property is controversial,its mechanism of action is not so clear,the clinical application is unreasonable,we should carry out its mechanism research under the guidance of its property theory,and use the contacted,developed thoughts in order to make it more effectively,reasonable implicated in clinical.