黄芩苷固体分散体的制备及差示扫描量热研究

目的:制备黄芩苷-PEG 4000固体分散体并研究黄芩苷的分散状态及其熔解过程的热力学性质.方法:采用熔融法制备黄芩苷-PEG4000固体分散体,用差示扫描量热法确定黄芩苷-PEG 4000物理混合物及固体分散体中黄芩苷熔解过程的热力学参数.结果:与物理混合物相比,固体分散体中黄芩苷的熔解焓较小,熔解过程的相变协同性较大.随着PEG 4000比例增大,固体分散体中黄芩苷的熔解温度、熔解焓和熔解相变协同性都逐渐增大.结论:黄芩苷在固体分散体中以微晶的形态存在,增大PEG 4000的比例将使黄芩苷在微观形态上更加均一.

Preparation and Differential Scanning Calorimetry Study of Solid Dispersions of Baicalin

Objective: To prepare solid dispersions of baicalin-PEG 4000 and investigate dispersed state and thermodynamic properties in melting process of baicalin. Method: Solid dispersions of baicalin-PEG 4000 was prepared by melting method,thermodynamic parameters in melting process of baicalin in solid dispersions and physical compound were determined by differential scanning calorimetry method. Result: Melting enthalpy of baicalin in solid dispersions was smaller than that in physical compounds,but phase transition cooperativity of melting process in solid dispersions was larger than that in physical compounds.All thermodynamic parameters of melting process in solid dispersions including melting temperature, melting enthalpy, and melting phase transition cooperativity increased with increasing the concentration of PEG 4000. Conclusion: Baicalin existed as minicrystal in solid dispersions and increasing the concentration of PEG 4000 will make baicalin more homogeneous.