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Chromosomal imbalances in four new uterine cervix carcinoma derived cell lines |
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| Authors: | Alfredo?Hidalgo,Alberto?Monroy,Rosa?Ma?Arana,Lucía?Taja,Guelaguetza?Vázquez,Mauricio?Salcedo author-information" > author-information__contact u-icon-before" > mailto:maosal@yahoo.com" title=" maosal@yahoo.com" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | 1.Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas,Hospital de Oncología, Centro Médico Nacional Siglo XXI-IMSS,Mexico;2.Laboratorio de Diferenciación Celular y Cáncer,FES Zaragoza, UNAM,Mexico;3.Servicio de Genética,Hospital General de México,Mexico;4.División de Investigación Básica,Instituto Nacional de Cancerología,Mexico |
| Abstract: | BackgroundUterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human papillomavirus (HPV) infection is considered to be the most important risk factor for the development of this tumor and cervical carcinoma derived cell lines are very useful models for the study of viral carcinogenesis. Comparative Genomic Hybridization (CGH) experiments have detected a specific pattern of chromosomal imbalances during cervical cancer progression, indicating chromosomal regions that might contain genes that are important for cervical transformation. |
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