鬼臼毒素及其衍生物新型制剂抗肿瘤作用研究进展

随着新辅料、新技术、新载体的不断涌现,鬼臼毒素及其衍生物的新剂型的研究呈现出广阔的前景.概述了鬼臼毒素在脂质体纳米粒、层状双氢氧物、聚合物胶束等新型载药系统中对多种肿瘤细胞的抗肿瘤作用；同时介绍了鬼臼毒素衍生物依托泊苷微球、口服微乳、纳米脂质体、β-环糊精包合物等新剂型在抗肿瘤研究中的靶向治疗、增加疏水性药物的溶解度、缓释作用方面的应用.随着鬼臼毒素及其衍生物的新型靶向制剂的进一步研究,可在降低毒副作用的同时增强其抗肿瘤作用,为合理开发鬼臼毒素及其衍生物的新剂型提供了研究基础.

Progress in New Preparations of Podophyllotoxin and its Derivatives for Anti-tumor Effect

With the new materials,new technologies and new emerging carriers,the research of novel dosage form of podophyllotoxin and its derivatives is opening up a broader prospect.Relevant literatures are collected,compiled for review.The applications of podophyllotoxin in liposome nanoparticles,layered double hydroxide,drug-loaded polymer micelles,and other new drug carrier system and its anti-tumor effect were introduced.The podophyllotoxin derivatives etoposide microspheres,oral microemulsion,nano-liposomes,β-cyclodextrin and other new formulations for anti-cancer in targeted therapy,increasing the solubility of hydrophobic drugs,sustained-release effect of the drug were also introduced.Further studies on podophyllotoxin and its derivatives as novel targeted agents will reduce toxicity and enhance the characteristics of anti-tumor effect.All these could serve as referential basis for the reasonable development of podophyllotoxin and its derivatives with new formulations.