香蕉皮多酚对高脂血症大鼠降血脂作用的实验研究

目的:研究香蕉皮多酚对高脂血症模型大鼠的降血脂作用.方法:健康SD雄性大鼠60只随机分为6组:正常对照组(NC)、模型对照组(MC)、阳性对照组(PC,辛伐他汀组)、香蕉皮多酚低剂量组(P1)、香蕉皮多酚中剂量组(P2)、香蕉皮多酚高剂量组(P3).NC组给予基础饲料；MC组给予高脂饲料；PC组给予高脂饲料,并灌胃给予辛伐他汀10 mg·kg-1,1次/日；P1,P2,P3组给予高脂饲料,并分别灌胃给予香蕉皮多酚(30,60,120 mg·kg-1),1次/日；均自由饮水,每周称1次大鼠体重.各组按规定给药40 d后,禁食12 h,眼眶静脉取血,分离血清,测定血清总胆固醇(TC)、血清三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C).结果:大鼠用高脂饲料喂养40 d后,与正常对照组相比,模型对照组TG(1.14±0.21 )mmol·L-1,TC(3.06±0.24) mmol·L -,LDL-C(2.97±0.12) mmol·L-1,水平明显升高,HDL-C(0.89 ±0.11)mmol· L-,水平降低(P＜0.05)；治疗组给予香蕉皮多酚后,与模型对照组相比,TC,TG和LDL-C水平明显降低,HDL-C水平升高(P＜0.05).结论:香蕉皮多酚具有一定的降血脂预防动脉粥样硬化形成的作用.

Study on the Antilipemic Effect of Banana Peel Polyphenols in Hyperlipidemic Rats

Objective: To study the antilipemic effect of banana peel polyphenols in hyperlipidemic rats. Method: Sixty healthy male SD rats were randomly divided into six groups: normal control group (NC), model control group (MC), positive control group (PC, simvastatin group), low dose group of banana peel polyphenols (P1), middle dose group of banana peel polyphenols(P2), high dose group of banana peel polyphenols(P3). The rats in the normal control group were fed with normal diet,and the MC groups were given high fat diet; the PC groups were given high fat diet, and given orally administrated with simvastatin at dose of 10 mg·kg^-1, semel in die; the P1, P2, P3,groups were given high fat diet, and orally administrated with banana peel polyphenol (30, 60, 120 mg·kg^-1), semel in die. After 40 days rats were sacrificed and blood sample was collected to evaluate serum total cholesterol (TC), serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C). Result: Compared with the NC group, the level of TG(1.14±0.21) mmol·L^-1,TC(3.06±0.24)mmol·L^-1,LDL-C(2.97±0.12)mmol·L^-1 in MC group was increased for, and HDL-C(0.89±0.11)mmol·L^-1 level was decreased in rats fed high fat diet(P<0.05),and then the levels of TC, TG and LDL-C in the treatment groups were decreased, and HDL-C levels were increased(P<0.05). Conclusion: It demonstrates that the banana peel polyphenols could effectivly reduce the levels of blood lipid in hyperlipidemic rats.