Novel ceramides from aerial parts of <Emphasis Type="Italic">Saussurea involucrata</Emphasis> Kar. et. Kir. |
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| Authors: | Wei Wu Yang Qu Huiyuan Gao Jingyu Yang Jianguo Xu Lijun Wu |
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| Institution: | (1) Phytochemical Engineering Group, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, P.R. China;(2) Graduate School of the Chinese Academy of Sciences, Beijing, 100049, P.R. China; |
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| Abstract: | Novel ceramides, together with nine known compounds were isolated from aerial parts of the Saussurea involucrata Kar. et. Kir. The novel structures were determined by spectroscopic methods and microscale chemical degradation. The ceramides
showed appreciable cytotoxicity against three human tumor cell lines including human promyelocytic leukemia (HL-60), human
melanoma (A375-S2) and human cervical carcinoma (HeLa) cell lines. The results suggested that this class of ceramides may
have potential as an antitumor agent. |
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