透析患者血清瘦素与微炎症状态关系的探讨

目的 探讨尿毒症患者高瘦素血症与微炎症状态的关系.方法 选择我院泌尿外科透析中心尿毒症患者73例为尿毒症组,另外选择同期体检中心健康体检者30名为对照组.比较2组体质量指数(BMI)、血肌酐(SCr)、尿素氮(BUN)、血清瘦素、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-10及外周血中性粒细胞吞噬功能...

Relationship between serum leptin and microinflammatory state in hamodialysis patients

Objective To explore the relationship between high leptin and mieroinflammatory state in uremic patients. Metlmds A group of 73 uremic patients in dialysis centre of our department was assigned as uremic group, and a group of 30 health persons who were examined over the same period served as normal group. The body mass index （BMI）, serum creatinine （SCr）, blood urea nitrogen （BUN）, leptin, tumor necrosis factor-alpha （TNF-α）, interleukin （IL）-6, IL-10 and the neutrophils phagoeytosis function were compared between two groups. Results BMI and IL-10 were lower, and the levels of SCr, BUN, leptin, TNF-α, IL-6 were higher in uremic group than in normal group （P〈0. 05）. The neutrophils phagocytosis function in uremic group was significantly decreased as compared with normal group （P〈0. 05）. One-way ANOVA analysis revealed that serum leptin was positively correlated with the levels of TNF-α and IL-6 （r= 0. 58 and 1.00,P〈0. 05）, but negatively with the levels of IL-10 （r= -0. 45, P〈0. 05）. Conclusions The high level of leptin and the related microinflarnmation are involved in the initiation and development of uremia, moreover leptin is an important mediator.