膀胱癌的凝集素受体分布与浸润和转移的关系

目的探讨凝集素受体分布与膀胱癌浸润和转移的关系。方法应用生物素标记的花生凝集素（PNA），菜豆凝集素（PHA）及扁豆凝集素（LCA）等3种凝集素对52例人体膀胱移行细胞癌，25例淋巴结转移癌，进行亲合组织化学法研究。结果发现PHA、PNA、受体阳性率在浸润性肿瘤中明显高于浅表性肿瘤（P<0．05。84%淋巴结转移癌与其原发膀胱癌在凝集素标记的量上有差异，并且比原发肿瘤获得更多的PNA及PHA受体。结论膀胱癌及淋巴结转移癌中PNA、PHA受体阳性率与膀胱癌浸润深度及淋巴结转移癌有关。

The distribution of lectin receptors in the bladder carcinoma and its relationship with invasion and metastasis

To study the distrbuition of lectin receptors in the bladder careinoma and its invasion andmetastasis. Methods Three lectins (Biotin-PNA, Biotin-PHA and Biontin-LCA) were used to study 52 casesof human bladder carcinoma and 25 cases of lymph node metastatic tumors by using the affinity histochemicalmethod. Results the positive rates of PNA and PHA receptors in invasive tumors were significant higher thanthe superficial ones (p<0. 05 ). 84.0% lymph node metastatic tumors produced celluar glycoconjugates, whichdiffered in lectin binding profiles from those made by the cells in the respective primary carcinoma. More PNAand PHA receptors were produced by the lymph node metastatic tumors than primary carcinoma. ConclusionThe positive rares PNA and PHA receptors are relative to the degree of invasion of bladder carcinoma and lymphnode metastatic tumors.