凝集素受体在膀胱癌中的分布

目的：探讨膀胱癌中凝集素受体分布与其分化程度和浸润深度的关系。方法：应用生物素标记的花生凝集素（ＰＮＡ）、麦胚凝集素（ＷＧＡ）及刀豆凝集素（ＣｏｎＡ）等３种凝集素对５２例人体膀胱癌、１０例正常人体膀胱粘膜，进行亲合组织化学法研究。结果：发现正常膀胱粘膜ＰＮＡ、ＷＧＡ受体阴性，ＰＮＡ受体阳性率随膀胱癌病理分级的上升而递增，差异具有显著性意义（Ｐ＜０．０５）。ＰＮＡ、ＷＧＡ受体阳性率在浸润性肿瘤中明显高于浅表性肿瘤（Ｐ＜０．０５）。结论：提示ＰＮＡ、ＷＧＡ受体阳性率与膀胱癌分化程度和浸润深度有关。

Distribution of lectin receptors in bladder carcinoma

Objective: To study whether the ditribution of lectin receptors in bladder carcinoma are relative to the degree of differentiation and invasion of bladder carcinoma. Methods: Three lectins (Biotin-PNA, Biotin-WGA and Biotin-ConA) were used to study 52 cases of human bladder carcinoma and 10 cases of normal bladder mucosa by using the affinity histochemical method. Results: No PNA and WGA were found in normal bladder mucosa. The positive rate of PNA receptors showed progressively increase in the cases of tumor grade. The statistical analyses showed a significant difference between the above three groups (P < 0 .05 ). The positive rates of PNA and WGA receptors in invasive tumors were significant higher than that in the superficial ones (P < 0.05). Conclusions: The Positive rates of PNA and WGA receptors are ralative to the degrees of diferentiation and invasion of bladder carcinoma.