面肌痉挛病因学机制的实验研究

目的 建立面肌痉挛动物(HFS)模型，探讨其病因及发病机理。方法28只新西兰大白兔随机分为模型组和对照组，采用颞浅动脉压迫人为脱髓鞘变的外周面神经主干的方法复制HFS动物模型，术后3、6周分别通过电生理技术诱发异常肌反应(AMR)。结果术后3周各组动物均未诱发AMR，术后6周在模型组动物上诱发AMR，而对照组动物仍无AMR。 结论动脉压迫面神经是HFS的发病原因；建立合适的HFS动物模型为进一步研究其发病机理提供了实验基础。

Experimental Study on the Etiological Mechanism of Hemifacial Spasm

Objective To investigate the etiology and pathogenesis of hemifacial spasm by estab-lishing animal models. Methods 28 New Zealand white rabbits were randomly divided into modelgroup and control group. The animal models of hemifacial spasm were replicated by compression of themain trunk of the artificial demyelinated facial nerve with the temporal superficial artery. The electro-physiological technique was used to explore the abnormal muscle reponse (AMR) at the third and sixthweek of postoperation respectively. Results No AMR was elicited in each group at the third week ofpostoperation, while AMR was elicited in model group rather than the other groups at the sixth week af-ter operation. Conclusion Aterial vascular compression on the facial nerve accounts for hemifacial spasm;Proper animal models of hemifacial spasm provide good experimental basis for the study of its pathogenesis.