乙型肝炎患者血清中HBV DNA的临床意义

目的 研究乙型肝炎病毒定量与疾病发生、发展的关系。方法 采用分子链信号扩增技术(bDNA)，检测172例乙肝患者血清中HBV DNA。结果各类型肝病患者血清病毒定量<0．7mmol／ml者所占各自比率分别为：急性88．0％，慢性32．3％，慢性重型66．7％，肝硬化19．4％，肝癌50．0％。46例慢乙肝肝活检显示：纤维化程度35岁以上组明显高于35岁以下组(P<0．01)。而96例慢乙肝病毒定量35岁以下组明显高于35岁以上组(P<0．01)。结论HBV的存在与复制是导致肝组织病变的最根本因素。

Significance of Detection of Serum HBV DNA in Hepatitis B Patients

Objective To study the relationship between the serum HBV DNA level and theprogress of hepatitis B. Methods HBV DNA was quantified by branch DNA signal amplification as-say(bDNA). 172 patients of different clinical types infected with HBV were investigated for HBVDNA. Results At the less than 0.7mmol/ml of HBV DNA level, 88.0% were acute patients,32.2% chronic,66.7% chronic with the fulminant hepatic failure, 19.4% cirrhotic, and 37.5% HCCpatients. The degree of fibrosis in the liver tissue is significantly higher in the group with more than 35years old. than in that with less than 35 years old ( P < 0.01 ). All chronic patients were analyzed,HBV DNA level is significantly higher in patients less than 35 years old than in patients more than 35years old ( P < 0.01 ). Conclusion This research demonstrated that existence and replication ofHBV were the main causes for the progress of hepatitis B.