Effect of oral naltrexone on pruritus in cholestatic patients |
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Authors: | Mansour-Ghanaei Fariborz Taheri Amir Froutan Hossein Ghofrani Hadi Nasiri-Toosi Mohsen Bagherzadeh Amir-Hossein Farahvash Mohammad-Jafar Mirmomen Shahram Ebrahimi-Dariani Naser Farhangi Elham Pourrasouli Zahra |
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Institution: | 1. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran 2. Digestive Disease Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran |
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Abstract: | AIM:To determine the efficacy and potential complica- tions of oral naltrexone used in the treatment of pruritus in cholestatic patients and to compare them with other studies. METHODS:Thirty-four enrolled cholestatic patients complaining of pruritus were studied.In the initial phase, pruritus scores during day and night were evaluated.Sub- sequently,patients were given a placebo for one week followed by naltrexone for one week.In each therapeutic course(placebo or naltrexone)day and night pruritus scores were distinguished by a visual analogue scale (VAS)system and recorded in patients'questionnaires. RESULTS:Both naltrexone and placebo decreased VAS scores significantly.Naltrexone was more effective than placebo in decreasing VAS scores.Both day and night scores of pruritus decreased by half of the value prior to therapy in thirteen patients(38%).Daytime pruritus improved completely in two patients(5.9%),but no im- provement in the nighttime values was observed in any patient. Sixteen patients(47%)suffered from naltrexone complications,eleven(32%)of them were related to its withdrawal.Complications were often mild.In the case of withdrawal,the complication was transient(within the first 24-28 h of therapy)and self-limited.We had to cease the drug in two cases(5.9%)because of severe withdrawal symptoms. CONCLUSION:Naltrexone can be used in the treatment of pruritus in cholestatic patients and is a safe drug showing few,mild and self-limited complications. |
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Keywords: | Cholestasis Pruritus Naltrexone |
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