Human auditory and somatosensory event-related potentials: effects of response condition and age |
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| Authors: | G Barrett R Neshige H Shibasaki |
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| Institution: | 1. Institute of Neurology, The National Hospital, Queen Square, London WC1N 3BG UK;2. Division of Neurology, Department of Internal Medicine, Saga Medical School, Nabeshima, Saga City 840-01 Japan;1. Department of Health & Exercise Science, Colorado State University, Fort Collins, CO, USA;2. Molecular, Cellular, and Integrative Neuroscience Program, Colorado State University, Fort Collins, CO, USA;1. DER, DEN, CEA, Cadarache, F-13108 Saint-Paul-lez-Durance, France;2. EC-JRC-Geel, B-2440 Geel, Belgium;3. Reactor Physics Division, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia;1. Department of Electrical Engineering, Urmia Branch, Islamic Azad University, Urmia, Iran;2. Department of Electrical Engineering, Amirkabir University of Technology, Tehran, Iran;1. MIND Institute, University of California-Davis, United States;2. Department of Psychiatry and Behavioral Sciences, U.C. Davis School of Medicine, United States;3. Division of Family Studies and Human Development, University of Arizona, United States;4. University of Washington, Seattle, WA, United States;5. Department of Pediatrics, U.C. Davis School of Medicine, Sacramento, CA, United States;1. Departement de Psychologie, Université de Montréal, Montreal, Canada;2. Neuroscience of Early Development (NED), Montreal, Canada;3. Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Montreal, Canada;4. Research Center of the CHU Ste-Justine Mother and Child University Hospital Center, Université de Montreal, Quebec, Canada;5. International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Quebec, Canada;6. Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal (CRIUSMM);7. Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM);1. Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland;2. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland;3. Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland;4. Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland;5. Institute of Clinical Medicine, Clinical Neurophysiology, University of Eastern Finland, Finland;6. The Finnish Association of People with Physical Disabilities, Validia Rehabilitation, Helsinki, Finland;7. Institute of Clinical Medicine, Clinical Radiology, University of Eastern Finland, Kuopio, Finland;8. Nexstim Plc, Helsinki, Finland;9. Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland |
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| Abstract: | In order to develop an experimental paradigm for clinical application of cognitive event-related potentials we have recorded these potentials in a group of 27 healthy Japanese, aged 20-78 years, using all 4 stimulus/response combinations of auditory or somatosensory stimuli requiring a counting or button-press response. In an oddball paradigm we recorded N1 and P2 components to frequent auditory stimuli and P100, N150 and P200 components to frequent somatosensory stimuli. These components were also observed in the target responses for their respective modalities together with N2, P270, P3 and slow-wave components. P3 latency increased linearly with age for all 4 experimental conditions, although this increase was not statistically significant for the somatosensory stimulus/button-press response combination. The latency of P270 also increased significantly with age for the auditory stimulus/button-press response combination but did not do so in either of the counting response conditions. The principal difference between the latencies of ERPs to auditory compared with somatosensory stimuli was that P3 was significantly longer for somatosensory stimulation, although differences in task difficulty may have influenced this finding. With regard to amplitude, N2, P3 and slow-wave were all significantly more positive for somatosensory compared with auditory stimulation. The topography of P3 evoked by somatosensory stimuli was most predominant at central electrodes, whereas the auditory P3 was larger parietally. The button-press response was associated with potentials which were smaller in amplitude and shorter in latency than those associated with the count response. The button-press response had a marked effect on the amplitude of P3 recorded at the vertex and the central electrode contralateral to the moving finger. |
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