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| 人参皂苷Rg1对脑缺血-再灌注大鼠海马CA1区神经元的保护作用及机制 | |
| 引用本文： | 刘霞,包翠芬,魏嘉,梁佳,秦书俭.人参皂苷Rg1对脑缺血-再灌注大鼠海马CA1区神经元的保护作用及机制[J].解剖科学进展,2010,16(2):177-180. |
| 作者姓名： | 刘霞 包翠芬 魏嘉 梁佳 秦书俭 |
| 作者单位： | 1. 辽宁中医药大学基础医学院组胚教研室,辽宁,沈阳,110032;辽宁医学院基础医学院组胚教研室,辽宁,锦州,121001 2. 辽宁医学院科学实验中心,辽宁,锦州,121001 3. 辽宁中医药大学基础医学院组胚教研室,辽宁,沈阳,110032;辽宁医学院基础医学院解剖学教研室,辽宁,锦州,121001 |
| 摘 要： | 目的探讨人参皂苷Rg1对脑缺血-再灌注大鼠海马CA1区神经元的保护作用及机制。方法将健康雄性SD大鼠随机分为假手术组,缺血再灌注组,人参皂苷Rg110、20、40mg/kg组,尼莫地平阳性药物对照组。采用Nissl染色检测大鼠缺血再灌注后海马神经元损伤,并采用免疫印迹方法检测p-JNK、p-c-jun、Bax的表达情况。结果假手术组海马神经元数量正常,p-JNK、p-c-jun、Bax含量最低;与假手术组比较,缺血再灌注组神经元数量显著降低,p-JNK、p-c-jun、Bax含量显著增高;各给药组与缺血再灌注组比较,海马神经元损伤减轻,p-JNK、p-c-jun、Bax含量降低,其中人参皂苷Rg140mg/kg组效果更明显。结论人参皂苷Rg1对大鼠脑缺血-再灌注损伤具有保护作用,可能与抑制脑组织p-JNK、p-c-jun、Bax的表达有关。 |
| 关 键 词： | 人参皂苷Rg1 脑缺血-再灌注 p-JNK p-c-jun Bax |
The protective role and mechanism of Ginsenoside Rg1 on the ischemic-reperfusion injuried neurons in hippocampus CA1 of rat |
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| LIU Xia,BAO Cui-fen,WEI Jia,LIANG Jia,QIN Shu-jian.The protective role and mechanism of Ginsenoside Rg1 on the ischemic-reperfusion injuried neurons in hippocampus CA1 of rat[J].Progress of Anatomical Sciences,2010,16(2):177-180. | |
| Authors: | LIU Xia BAO Cui-fen WEI Jia LIANG Jia QIN Shu-jian |
| Institution: | 1.Department of Histology and Embryology,College of Basic Medical Sciences,Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110032;2.Department of Histology and Embryology,College of Basic Medical Sciences,Liaoning Medical College,Liaoning Jinzhou 121001;3.Centre of Scientific Expreiment,Liaoning Medical College,Liaoning Jinzhou 121001;4.Department of Anatomy,College of Basic Medical Sciences,Liaoning Medical College,Liaoning Jinzhou 121001 China) |
| Abstract: | Objective To explore the protective role and mechanism of Ginsenoside Rg1 on the ischemic-reperfusion injuried neurons in hippocampus CA1 of rat.Methods Healthy male SD rats were randomly divided into the sham-operative group,focal cerebral ischemia-reperfusion group,Ginsenoside Rg1 treated groups(Rg1 10,20,40 mg/kg),and Nimodiping treated group.Nissl staining and Western blot were used to detect neurons and the expression of p-JNK,p-c-jun and Bax.Results The percentage of neurons was decreased and the expr... |
| Keywords: | Ginsenoside Rg1 ischemic-reperfusion p-JNK p-c-jun Bax |
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