Clinical experience with molecular adsorbent recirculating system (MARS) in patients with drug-induced liver failure |
| |
Authors: | Zhou Xin-Min Miao Ji-Yan Yang Yan Zhao Ling Wang Xin Xu Li Ding Jie Wu Kai-Chun Fan Dai-Ming Wang Min-Min |
| |
Affiliation: | Institute of Digestive Diseases, Xi'jing Hospital, Fourth Military Medical University, Xi'an, China. |
| |
Abstract: | The molecular adsorbent recirculating system (MARS) is a novel extracorporeal technique for liver support. We report the clinical results in a group of fourteen patients with drug-induced liver failure. Fourteen patients, aged 22-83 years, with acute or subacute liver failure [mean Child-Turcotte-Pugh (CTP) score 11 (range 8-15)] due to the intake of various drugs (diet pill overdose-2; Chinese traditional medicine (CTM)-4; antibiotic, paracetamol, tuberculostatic, or vasodilator abuse-8) were treated with one to seven sessions of MARS. Beneficial effects such as the improvement of encephalopathy and prothrombin activity, as well as a reduction of bilirubin and ammonia were recorded during MARS treatments. Thirteen out of fourteen patients survived the hospitalization (93%), and two of the discharged patients died during the follow-up of 6-12 months. The overall survival rate was about 79%. MARS therapy can contribute to the improved treatment of drug-induced liver failure patients. |
| |
Keywords: | Artificial liver Molecular adsorbent recirculating system Drug induced Liver failure |
本文献已被 PubMed 等数据库收录! |
|