正常人群肾综合征出血热抗体动态变化的纵向观察

1988年4~12月份,我们对安撤省颍上县疫区2 796人进行了血清流行病学定群研究,结果发现随着月份的增加,人群的抗体水平在升髙,各季节室内鼠密度及带病毒率变化不明显,但是9月份野外鼠密度及带病毒率有一明显的髙峰,这说明野外鼠密度及带病毒率是引起抗体动态变化及发病高峰的主要原因。临床感染与亚临床感染之比为1:26,我们认为肾综合征出血热感染主要以亚临床感染为主。这提示我们研究和防治出血热,不但要研究临床病人,还要研究无症状的亚临床感染。

The Cohort Study on HFRSV Antibody Variation in Normal Population of an Epidemic Area

We randomly selected 2,796 persons in an epidemic area of HFRS in Anhui province for serological study from April to December in 1988. The results showed that the antibody prevalence rates were 7.3%, 10% and 14% respectively in April, September and December. Their GMT were 1.30, 1.42 and 1.73 respectively. Indoor rodent density and HFRSV carrying rate were respectively 7.8%, 6.4% in April, 9.4%, 8.8% in September, and 7.5%, 8.2% in December. Outdoor rodent density and HFRSV carrying rate were respectively 10.0%, 6.8% in April, 29.5%, 12.2% in September, and 10.8%, 11.0% in December. The positive seroconversion rate was 6.0% and negative seroconversion rate was 18.0%. The ratio of clinical infection to subclinical infection was 1:26. It is conclude that subclinical infection is dominant in HFRS infection, outdoor rodent density and their HFRSV carrying rate are the main factors for the infection in this HFRS endemic area.