Mucin gene expression in the human endocervix |
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| Authors: | Audie, Jean-Pierre Tetaert, Daniel Pigny, Pascal Buisine, Marie-Pierre Janin, Anne Aubert, Jean-Pierre Porchet, Nicole Boersma, Arnold |
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| Affiliation: | 1Unité INSERM 377 Place de Verdun 2Laboratoire de Biochimie Endocrinologique USN A 3Laboratoire d'Anatomie Cytologie Pathologique C, Hopital A.Calmette C H et U, Lille, France 4Laboratoire de Biochimie, Hopital C.Huriez C H et U, Lille, France |
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| Abstract: | In the human uterine endocervix, five out of the six human mucingenes investigated (MUC 2, MUC 3, MUC 4, MUC 5AC, MUC 5B andMUC 6) are expressed, whereas in some other mucosae the hybridizationpattern demonstrates the expression of only two or three ofthese genes. The most intense labelling by in-situ hybridizationis obtained significantly with MUC 4, predominantly during theluteal phase. The expression of the MUC 4 gene appears to beinfluenced by the oestro-progesterone ratio. During the ovulatorycycle, there are only a few differences concerning the variationsof expression of all other MUC genes. |
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| Keywords: | endocervix/in-situ hybridization/mucin gene |
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