胺碘酮治疗心力衰竭伴快速房颤的短时疗效观察

目的：探讨经胺碘酮对心力衰竭并发快速房颤予以诊治的短时疗效。方法随机将83例患有HF （心力衰竭）与AF（快速房颤）者分组：心衰房颤组（40例）与对照并发组（43例）。心衰房颤组经常规＋胺碘酮，对照并发组经西地兰或地高辛治疗，随后，比较心衰房颤组与对照并发组的心室率变化、心功能以及不良反应。结果相比经胺碘酮或者西地兰治疗前，心衰房颤组与对照并发组的心室率在用药之后均显著改善，P〈0.05。比较心衰房颤组与对照并发组的心室率改善情况，心衰房颤组比对照并发组更早起效、改善更显著，P〈0.05，比较心衰房颤组与对照并发组的心衰体征治疗效果，心衰房颤组比对照发病组好，P〈0.05。对比心衰房颤组与对照并发组用药不良反应，心衰房颤组明显好于对照并发组，P〈0.05。结论用胺碘酮诊疗心力衰竭及快速房颤，可使心室率和心功能分别得到有效控制、显著改善。

Short-term efficacy of amiodarone in treatment of heart failure with rapid atrial fibrillation

Objective To investigate the short-term efficacy of amiodarone in the treatment of heart failure （HF） with rapid atrial fibrillation （AF）. Method Eighty-three patients with HF plus rapid AF were randomly divided into observation group （n=40） and control group （n=43）. The observation group received conventional treatment and amiodarone, while the control group received cedilanid or digoxin. The two groups were compared in terms of ventricular rate, cardiac function, and adverse events. Results After treatment, both groups showed significant improvements in ventricular rate （P〈0.05）; compared with the control group, the observation group had significantly earlier and more improvements in ventricular rate （P〈0.05）, significantly more improvement in signs of HF （P〈0.05）, and significantly fewer adverse events （P〈0.05）. ConclusionAmiodarone can effectively control ventricular rate and significantly improve cardiac function in the treatment of HF with rapid AF.