Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis |
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Authors: | Kamal Esalatmanesh Raika Jamali Arsia Jamali Bardia Jamali Mohammadreza Nikbakht |
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Affiliation: | 1. Internal Medicine Ward, Division of Rheumatology, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran 2. Anatomical Sciences Research Center, Students?? Scientific Research Center, Internal Medicine Ward, Kashan University of Medical Sciences, Kashan, Iran 3. Students?? Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran 4. Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
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Abstract: | To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was measured. There was correlation between serum anti-CCP and DAS28-ESR. (R 2?=?0.71, P value?0.01). New disease activity index was developed by replacing anti-CCP with ESR in DAS28-ESR. There was correlation between new model and DAS28-ESR. (R 2?=?0.91, P value?0.01) The new composite index best cut-off values corresponding to DAS28-ESR values of 2.6, 3.2, and 5.1 were 3.21, 3.38, and 4.74, respectively. There was agreement between new model and DAS28-ESR for determination of patients in different disease activity categories. (Kappa?=?0.71, P value?0.01). The new disease activity index that applies serum anti-CCP may predict disease activity in RA. |
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