| 诱发性大鼠肝硬化性肝癌超顺磁性氧化铁增强MRI与电镜表现 |
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| 引用本文： | 赵云辉,许乙凯.诱发性大鼠肝硬化性肝癌超顺磁性氧化铁增强MRI与电镜表现[J].临床放射学杂志,2008,27(12):1772-1776. |
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| 作者姓名： | 赵云辉 许乙凯 |
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| 作者单位： | 兰州军区乌鲁木齐总医院医学影像科,新疆,830000;南方医科大学南方医院影像中心,广州,510515 |
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| 摘 要： | 目的 研究诱发性大鼠肝硬化性肝癌超顺磁性氧化铁(SPIO)增强MRI与电镜表现. 材料与方法 16只由二乙基亚硝胺(DENA)诱导的肝硬化性肝癌大鼠行肝脏SPIO增强前后MR扫描,再行肝脏病理学及电镜检查. 结果 肝癌在T1WI上为低或等低信号,T2WI为较高信号.SPIO增强T2WI上,正常肝实质、肝硬化组织信号强度(SI)较增强前明显下降,肝癌SI较增强前无明显下降,其对比噪声比(CNR)升高,病变显示清晰.SPIO增强T1WI上正常肝实质及硬化肝组织SI无明显下降,肝癌SI较增强前升高,其CNR较增强前降低,病变显示不清楚.电镜下正常肝组织枯否细胞(KC)内溶酶体丰富,可见较多黑色颗粒状SPIO粒子,胞浆内可见大的SPIO簇.肝硬化组织细胞间隔增宽,胶原纤维明显增多,KC数量无明显减少,其内溶酶体有所减少,可见散在SPIO粒子,胞浆内可见较大的SPIO簇.肝癌组织KC数量减少或消失,癌细胞内细胞器基本消失,核异型. 结论 诱导性大鼠肝硬化性肝癌MR信号表现与人类肝癌相似.SPIO增强肝脏信号改变和KC数量及吞噬功能有一定关系.SPIO增强T2WI不仅能提高肝癌的对比,且能间接反映KC数量,可以预测肝癌组织学分级.
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| 关 键 词： | 大鼠 肝硬化 肝癌 磁共振成像 超顺磁性氧化铁 枯否细胞 |
SPIO Enhanced MRI and TEM Findings of the Rat with Cirrhosis and Hepatocellular Carcinoma Induced by DENA |
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| ZHAO Yunhui,XU Yikai.SPIO Enhanced MRI and TEM Findings of the Rat with Cirrhosis and Hepatocellular Carcinoma Induced by DENA[J].Journal of Clinical Radiology,2008,27(12):1772-1776. |
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| Authors: | ZHAO Yunhui XU Yikai |
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| Institution: | ZHAO Yunhui,XU Yikai Department of Medical Imaging,Wurmqi Army General Hospital,Wurmqi,Xinjiang Weiwuer Autonomous Reginon 830000,P.R.China |
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| Abstract: | Objective To study magnetic resonance imaging (MRI) findings before and after superparamagnetic iron oxide (SPIO) enhancement and transmission electron microscope (TEM) changes of the rat with hepatocellular carcinoma (HCC) and cirrhosis induced by DENA. Materials and Methods Sixteen rat models with HCC and cirrhosis induced by Diethylnitrosamine (DENA) were performed MRI scan before and after SPIO enhancement.After MRI scan, liver tissues were observed under HE staining and TEM. Results HCC was hypointensi... |
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| Keywords: | Rat Cirrhosis Hepatocellular carcinoma Magnetic resonance imaging Superparamagnetic iron oxide Kupffer cell |
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