Neuraminic acid is involved in the binding of influenza C virus to erythrocytes |
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Authors: | G Herrler R Rott H D Klenk |
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Institution: | Institut für Virologie, Justus-Liebig-Universität Giessen, D-6300 Giessen, Federal Republic of Germany |
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Abstract: | Neuraminidases of both viral and bacterial origin have been reported to be unable to destroy the cellular receptor for influenza C virus on chicken erythrocytes, in contrast to the receptors for influenza A and B virus. However, under appropriate conditions neuraminidases from both Vibrio cholerae and Clostridium perfringens were able (i) to make chicken red blood cells resistant against agglutination by influenza C virus and (ii) to reduce the hemagglutination-inhibiting activity of rat serum. Both effects were abolished in the presence of the neuraminidase inhibitor 2,3-dehydro-2-deoxyneuraminic acid (DDN). These results indicate that contrary to previous assumptions sialic acid may very well be an essential component of the receptor for influenza C virus. |
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Keywords: | Author to whom requests for reprints should be addressed |
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