| C-Rel与Bcl-xL在脑缺血再灌注大鼠脑组织中的表达及意义 |
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| 引用本文： | 龚家明,罗勇,王咏龙,何兰英,蔡志友.C-Rel与Bcl-xL在脑缺血再灌注大鼠脑组织中的表达及意义[J].第四军医大学学报,2009,30(4):327-330. |
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| 作者姓名： | 龚家明 罗勇 王咏龙 何兰英 蔡志友 |
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| 作者单位： | 重庆医科大学附属第一医院神经内科,重庆市神经病学重点实验室,重庆,400016
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| 摘 要： | 目的：检测脑缺血再灌注大鼠脑组织C-Rel与Bcl-xL表达，探讨NF-κB信号通路在缺血性脑损伤中的作用机制。方法：大脑中动脉线栓法制作脑缺血再灌注动物模型，随机分为正常组（N组）、假手术组（S组）、缺血2h后再灌注2h组（M2组）、6h组（M6组）、12h组（M12组）、24h组（M24组）。RT-PCR和免疫组织化学法检测C-Rel与Bcl-xL，用图像分析仪测定吸光度值。结果：模型组与正常组、假手术组比较，C-Rel与Bcl-xL表达增高（P〈0.01），4个模型组比较无统计学差异，C-Rel与Bcl-xL表达有正相关性。结论：C-Rel与Bcl-xL在脑缺血再灌注大鼠脑组织表达增高，NF-κB家族C-Rel通过增强抗凋亡基因Bcl-xL表达发挥脑保护作用。
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| 关 键 词： | 脑缺血 再灌注 NF-κB 信号传导 细胞凋亡 |
Expression of C-Rel and Bcl-xL in rat brain with focal cerebral ischemia-reperfusion and its significance |
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| GONG Jia-Ming,LUO Yong,WANG Yong-Long,HE Lan-Ying,CAI Zhi-You.Expression of C-Rel and Bcl-xL in rat brain with focal cerebral ischemia-reperfusion and its significance[J].Journal of the Fourth Military Medical University,2009,30(4):327-330. |
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| Authors: | GONG Jia-Ming LUO Yong WANG Yong-Long HE Lan-Ying CAI Zhi-You |
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| Institution: | GONG Jia-Ming,LUO Yong,WANG Yong-Long,HE Lan-Ying,CAI Zhi-You Department of Neurology,First Affiliated Hospital,Chongqing University of Medical Scineces,Key Laboratory of Neurology in Chongqing,Chongqing 400016,China |
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| Abstract: | AIM: To investigate the expression of C-Rel and Bcl-xL in Wistar rats with focal cerebral ischemia-reperfusion injury and to study the pathophysiological mechanism of signal pathway of nuclear factor-kappa B in cerebral ischemia injury.METHODS: Wistar rat models of focal cerebral ischemia-reperfusion injury were established by middle cerebral artery occlusion(MCAO) and were randomly divided into normal group(N),sham-operation group(S) and cerebral ischemia reperfusion groups(M),which were subdivided into 2 ... |
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| Keywords: | brain ischemia reperfusion NF-kappa B signal transduction apoptosis |
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