| 溶栓抗凝联合治疗大鼠急性血栓后对局部管壁的影响 |
| |
| 引用本文： | 杨冰,赵庆华,赵渝.溶栓抗凝联合治疗大鼠急性血栓后对局部管壁的影响[J].重庆医科大学学报,2010,35(2). |
| |
| 作者姓名： | 杨冰 赵庆华 赵渝 |
| |
| 作者单位： | 重庆医科大学附属第一医院护理学院,重庆,400016;重庆医科大学附属第一医院护理部,重庆,400016;重庆医科大学附属第一医院血管外科,重庆,400016 |
| |
| 摘 要： | 目的:研究尿激酶、肝素及其联合治疗急性大鼠下腔静脉血栓(DeeP venous thrombosis,DVT)形成后不同时相静脉血栓与血管粘附特性的变化.方法:SD大鼠140只,105只建立大鼠急性下腔静脉血栓模型后随机分为肝素治疗A组、尿激酶治疗B组、联合治疗C组各35只;另35只为假手术组(sham,SH).各组给药后分别于血栓形成后第1、4、7、14、28 d获取目标血管,光镜观察血栓的结构演变与机化、内膜增生程度,检测静脉壁平滑肌胶原沉积量.以及力学测量管壁血栓附着力.结果:A组内膜增生最严重.栓后1、4 d,B、C组血栓附着力分别较A组低(P<0.01).结论:尿激酶加肝素治疗大鼠急性下腔静脉血栓形成能有效地保护内皮层完整,减轻血管内膜增生,但在溶栓抗凝联合治疗急性血栓后残余附壁血栓粘附力相对较低,不建议早期运动加压.
|
| 关 键 词： | 静脉血栓形成 抗凝溶栓 内膜增生 粘附 |
Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats |
| |
| YANG Bing,et al.Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats[J].Journal of Chongqing Medical University,2010,35(2). |
| |
| Authors: | YANG Bing |
| |
| Institution: | YANG Bing,et al (Department of Nursing,the First Affiliated Hospital,Chongqing Medical University) |
| |
| Abstract: | Objective:To study the changes of thrombotic adhersion property and inferior caval vein wall after acute thrombosis with therapeutic alliance in rats.Methods:The inferior caval venous thrombosis model were treated with heparin(group A,n=35),urokinase (group B,n=35),and the combination of heparin and urokinase(group C,n =35),respectively.(group SH,n =35).The thrombosed caval veins were taken 1,4,7,14,and 28 days after thrombosis.The changes of thrombotic tructure and intima hyperplasia.were observed by light... |
| |
| Keywords: | Venous thrombosis Anticoagulation thrombolysis Intimal hyperplasia Adhesion |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
