生物材料血液相容性体外评价的研究进展

体外实验因其快捷、方便、特点 ,通常被用作生物材料血液相容性评价的初步筛选实验。在体外血液相容性评价中 ,需选用合理的血液与材料接触模型、敏感而又特异的检测指标 ,在整个实验中尽量避免外界非待测材料对血液的激活作用。另外接触时间、接触方式、切变率以及参照材料的选择等均是重要的影响因素。近年来 ,体外评价方法虽已取得很大进展 ,但仍有待于标准化 ,以更有效地评价生物材料的血液相容性。

In-vitro Evaluation of Haemocompatibility of Biomaterials

In-vitro test is usually conducted as a preliminary screening test in the evaluation of the haemocompatibiltiy of biomaterials for its short-term consuming, convenience and less expense. The selection of appropriate model for blood-biomaterial interaction, the choice of sensitive and specific parameters, and the minimization of additional blood activation are most important in the in-vitro test. In addition, the time and the style of blood-biomaterial interaction, the choice of sensitive and specific parameters, and the minimization of additional blood activation are most important in the in-vitro test. In addition, the time and the style of blood-biomaterial interaction, the selection of primary reference materials and the shear rate should be considered. In recent years, though great progress has been made in the in-vitro evaluation of haemocompatibility of biomaterials, all these influencing factor should be standardized for more effective evaluation of the haemocompatibiltiy of biomaterials.