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Pharmacological characterization of grooming induced by a selective NK-1 tachykinin receptor agonist |
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| Authors: | A Jon Stoessl Muriel Brackstone Nagalingham Rajakumar Candace J Gibson |
| Institution: | aClinical Neurological Sciences, University of Western Ontario and Robarts Research Institute, London, Ont., Canada bDepartment of Pathology, University of Western Ontario, London, Ont., Canada |
| Abstract: | Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist AcArg6, Sar9, Met(O2)11]SP6–11 (0–11 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), but not by NK-2 (L-659, 877) or NK-3 (Trp7, β-Ala8]NKA4–10) antagonists. Pretreatment with systemic opioid (naloxone 1.5 mg/kg) and D1 dopamine (SCH 23390 100 μg/kg) receptor antagonists also attenuated tachykinin-induced grooming, which was unaffected by D2 dopamine (sulpiride 30 mg/kg) or 5-HT2A+C (ritanserin 2 mg/kg) antagonists. Grooming induced by intranigral AcArg6, Sar9, Met(O2)11]SP6–11 was also attenuated by bilateral 6-hydroxydopamine lesions of te substantia nigra. These findings indicate that grooming induced by intranigral tachykinins reflects activation of NK-1 receptors and is dependent upon endogenous dopamine and consequent selective stimulation of D1 dopamine receptors. |
| Keywords: | Dopamine D1 receptor Grooming Substantia nigra Tachykinin |
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