| 大鼠睾丸间质tau蛋白和微管结合蛋白表达的变化 |
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| 引用本文： | 刘子龙,王刚,张万宏,刘胜洪,王小丽,王芳,康学军. 大鼠睾丸间质tau蛋白和微管结合蛋白表达的变化[J]. 中华男科学杂志, 2004, 10(1): 35-38 |
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| 作者姓名： | 刘子龙 王刚 张万宏 刘胜洪 王小丽 王芳 康学军 |
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| 作者单位： | 1. 华中科技大学同济医学院计划生育研究所,湖北,武汉,430030
2. 华中科技大学同济医学院解剖学系,湖北,武汉,430030 |
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| 摘 要： | 目的 :检查老龄和青年大鼠睾丸间质组织中tau蛋白和微管结合蛋白的表达情况 ,籍此评价老龄大鼠睾丸衰退的发生机制。 方法 :应用二步法免疫组化技术检查 6月龄SD雄性大鼠 (10只 ,青年组 )和 2 8月龄同品系大鼠 (10只 ,老龄组 )睾丸组织抗Tau蛋白和抗微管结合蛋白的抗体免疫反应情况。 结果 :老龄大鼠睾丸间质组织中tau蛋白免疫反应阳性细胞数明显高于青年组 (P <0 .0 0 1) ,而青年组大鼠睾丸间质组织中微管结合蛋白免疫反应阳性细胞数明显高于老龄组 (P <0 .0 1)。 结论 :tau蛋白和微管结合蛋白免疫反应阳性细胞数量的变化可能与睾丸衰退有密切关系
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| 关 键 词： | tau蛋白 微管结合蛋白 睾丸间质 衰退 大鼠 |
| 文章编号： | 1009-3591(2004)01-0035-04 |
| 修稿时间： | 2003-07-07 |
Expression Changes of tau Protein and Microtubule-associated Proteins in Testis Intersitium of Rats |
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| Liu Zilong,Wang Gang,Zhang Wanhong,Liu Shenghong,Wang Xiaoli,Wang Fang,Kang Xuejun Family Planning Institute. Expression Changes of tau Protein and Microtubule-associated Proteins in Testis Intersitium of Rats[J]. National journal of andrology, 2004, 10(1): 35-38 |
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| Authors: | Liu Zilong Wang Gang Zhang Wanhong Liu Shenghong Wang Xiaoli Wang Fang Kang Xuejun Family Planning Institute |
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| Affiliation: | Family Planning Institute, Tongji Medical College of Huazhong Science and Technology University, Wuhan, Hubei 430030, China. |
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| Abstract: | OBJECTIVE: To examine the expression of the tau protein and microtubule-associated proteins in the testis interstitium of aged and young rats. METHODS: Sprague-Dawley male rats were divided into a young group(6 months, n = 10) and an aged group(28 months, n = 10). The two steps immunohistochemistry method with the antibody against tau protein and MAP alpha was performed on the testis tissues of the rats. RESULTS: The results showed that the immunoreactive cells of tau protein of the testis interstilial of the aged rats obviously increased(P < 0.001) than those of the young, while the immunoreactive cells of the microtubule-associated proteins decreased(P < 0.01) in the aged. CONCLUSION: The changes in the expression of the tau protein and microtubule-associated proteins may be related to the aging process of the testis. |
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| Keywords: | tau protein microtubule-associated proteins rat testis interstitial aging immunohistochemistry |
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