| 唐氏综合征和脓毒症患儿的死亡风险 |
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| 引用本文： | Garrison M. M. Jeffries H. Christakis D. A.. 唐氏综合征和脓毒症患儿的死亡风险[J]. 世界核心医学期刊文摘, 2006, 2(6): 24-25 |
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| 作者姓名： | Garrison M. M. Jeffries H. Christakis D. A. |
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| 作者单位： | [1]Garrison, Child Health Institute, University of Washington, Box354920, Seattle, WA98195-4920, United States [2]不详, Child Health Institute, University of Washington, Box354920, Seattle, WA98195-4920, United States |
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| 摘 要： | 目的：明确唐氏综合征（DS）患儿与一般儿童在致命性疾病方面的差异。试验设计：利用儿童健康信息系统（PHIS）数据库，该数据库包括来自于独立的儿童医院人口统计学和诊断学资料。在控制潜在的混杂因素后，作者应用Poisson回归分析法来确定DS患儿合并脓毒症时死亡的风险性。结果：总共有35645例患者符合纳入标准，其中3936（11％）例在住院期间死亡。在所纳入的病例中总共有620例被诊断为DS；其中106（17％）患者住院期间死亡。校正潜在的混杂因素，包括人口统计学因素、病原学因素和其他伴随条件后，DS患儿的死亡率明显较高（死亡率RR 1．30，95％CI 1．06～1．59）。
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| 关 键 词： | 唐氏综合征 脓毒症 患儿 死亡风险 Poisson 人口统计学 儿童健康 混杂因素 住院期间 回归分析法 |
Risk of death for children with Down syndrome and sepsis |
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| Garrison;M.;M.;Jeffries;H.;Christakis;D.;A.. Risk of death for children with Down syndrome and sepsis[J]. Digest of the World Core Medical Journals:Ophthalmology, 2006, 2(6): 24-25 |
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| Authors: | Garrison M. M. Jeffries H. Christakis D. A. |
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| Abstract: | We report the case of a 32-year-old Indian man with symptoms suggesting Zollinger-Ellison syndrome including abdominal pain, esaphagitis, duodenal stenosis that did not improve with antisecretory medication, elevated fasting gastrin serum levels that increased after intravenous secretin injections, elevated chromogranin A serum levels and tumoral aspect of pancreatic uncus on CT scan examination. A pancreaticoduodenectomy was performed. Histological examination of the resected specimen showed that there was no endocrine tumour of the pancreas or the duodenum, but identified marked lesions of follicular and caseous tuberculosis. The final diagnosis retained pseudo Zollinger-Ellison syndrome due to gastric outlet obstruction caused by duodenal stenosis of a tuberculosis origin. |
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