乙型肝炎病毒表面抗原定量检测临床意义的探讨

为探讨乙型肝炎病毒表面抗原（ＨＢｓＡｇ）定量检测作为反映乙型肝炎病毒（ＨＢＶ）复制情况的临床意义，本文对２００例ＨＢｓＡｇ阳性标本分别做ＨＢｓＡｇ定量检测和ＨＮＢ－ＤＮＡ检测，血清学标志物检测，并对１０例患者地行随访检测以上项目。根据测得的ＨＢｓＡｇ含量将２００例标本分为五组，计算出各组ＨＢＶ－ＤＮＡ阳性率，发现随ＨＢｓＡｇ含量增高，ＨＢＶ－ＤＮＡ阳性率也显著增高（Ｐ〈０．０１）。根据ＨＢＶｅ系统不同模式分组显示，随ＨＢＶ感染好转，ＨＢｓＡｇ含量也随之降低（Ｐ〈０．０５）。对６例ＨＢＶ－ＤＮＡ转阴患者ＨＢＶ－ＤＮＡ转阴前后的ＨＢｓＡｇ含量比较，发现随ＨＢＶ－ＤＮＡ转阴，ＨＢｓＡｇ量也显著降低（Ｐ〈０．０１）。综合以上结果，可以说明血清中ＨＢｓＡｇ含量，可以间接反映体内ＨＢＶ的情况，ＨＢｓＡｇ定量检测可作为间接反

The Study of HBsAg Quantitative Detection

To study the clinical value of HBsAg quantitative detection in reflecting the HBV copy condition, the levels of HBsAg and HBV-DNA were detected in 200 patients with HBsAg positive, and in which 10 patients were followed up for 6 months. The results showed that HBV-DNA positive percentage increased remarkably with HBsAg increasing ( P <0.01). The changes in HBeAg and HBeAb in different pattern indicate that the level of HBsAg decreased with convalescing of hepatitis B( P <0.05). In 6 patients whose HBV-DNA changed to positive, the level of HBsAg decreased significantly( P <0.01). Conclusion: HBsAg quantitative detection is suitable for analysis of HBV copy condition.