Predictors of serum dioxin levels among adolescent boys in Chapaevsk, Russia: a cross-sectional pilot study |
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| Authors: | Hauser Russ Williams Paige Altshul Larisa Korrick Susan Peeples Lynne Patterson Donald G Turner Wayman E Lee Mary M Revich Boris Sergeyev Oleg |
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| Institution: | (1) Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, I-1405, Boston, MA 02115, USA;(2) Department of Biostatistics, Harvard School of Public Health, 665 Huntington Avenue, I-415, Boston, MA 02115, USA;(3) Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, I-B26, Boston, MA 02115, USA;(4) Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Channing Laboratory 336, 11 Longwood Avenue, Boston, MA 02115, USA;(5) Center for Disease Control and Prevention, Toxicology Branch Mailstop F-17, TOX/EHLS/NCEH/CDC, 4770 Buford Hwy NE, Atlanta, GA 30341, USA;(6) Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01532, USA;(7) Center for Demography and Human Ecology of Institute for Forecasting, Russian Academy of Sciences, RAS. 47 Nahimowski Avenue, Moscow, 117418, Russia;(8) Chapaevsk Medical Association, Lenina Str., 54B, Chapaevsk, Samara reg., 446100, Russia |
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| Abstract: | Background Toxicological studies and limited human studies have demonstrated associations between exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) and adverse developmental and
reproductive health effects. Given that children may be particularly susceptible to reproductive and developmental effects
of organochlorines, and the paucity of information available regarding childhood exposures to dioxins in particular, we undertook
a pilot study to describe the distribution of, and identify potential predictors of exposure to, dioxin-like compounds and
dioxins among adolescent boys in Chapaevsk, Russia. The pilot study was also designed to guide the development of a large
prospective cohort study on the relationship of exposure to PCDDs, PCDFs, and PCBs with growth and pubertal development in
peri-pubertal Chapaevsk boys. |
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